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DAFNA Capital Management LLC Nathan Fischel

Los Angeles, CA 20 processed 13Fs on this site, 2021 Q3 to 2026 Q2

  • $524M
  • 88 holdings
  • 2026 Q2
  • +19.1% QoQ
  • Top 5 40.2%

Portfolio

2026 Q2, filed 8/14/2026, top 12 of 88 holdings

Top 5 40.2%, top 10 56.2%

  1. RVMD, Revolution Medicines 20.1%
  2. XBI, SPDR S&P Biotech ETF 5.9%
  3. CMPS, Compass Pathways 5.4%
  4. STXS, Stereotaxis 4.5%
  5. NKTR, Nektar Therapeutics 4.3%
  6. DNLI, Denali Therapeutics 3.6%
  7. IDYA, Ideaya Biosciences 3.5%
  8. ATRC, Atricure 3.2%
  9. XENE, Xenon Pharmaceuticals 2.9%
  10. CYTK, Cytokinetics 2.8%
  11. RCUS, Arcus Biosciences 2.6%
  12. ASND, Ascendis Pharma A/s 2.5%
  13. Other 38.7%

AUM over time

2026 Q2 $524M +19.1% QoQ
2021 Q3: $377M 2021 Q3: $377M
Q3 2021
2021 Q4: $398M, +5.6% QoQ 2021 Q4: $398M, +5.6% QoQ
Q4
2022 Q1: $384M, −3.5% QoQ 2022 Q1: $384M, −3.5% QoQ
Q1 2022
2022 Q2: $367M, −4.4% QoQ 2022 Q2: $367M, −4.4% QoQ
Q2
2022 Q3: $372M, +1.4% QoQ 2022 Q3: $372M, +1.4% QoQ
Q3
2022 Q4: $355M, −4.6% QoQ 2022 Q4: $355M, −4.6% QoQ
Q4
2023 Q1: $334M, −5.9% QoQ 2023 Q1: $334M, −5.9% QoQ
Q1 2023
2023 Q2: $366M, +9.6% QoQ 2023 Q2: $366M, +9.6% QoQ
Q2
2023 Q3: $321M, −12.3% QoQ 2023 Q3: $321M, −12.3% QoQ
Q3
2023 Q4: $417M, +29.9% QoQ 2023 Q4: $417M, +29.9% QoQ
Q4
2024 Q1: $439M, +5.3% QoQ 2024 Q1: $439M, +5.3% QoQ
Q1 2024
2024 Q2: $419M, −4.6% QoQ 2024 Q2: $419M, −4.6% QoQ
Q2
2024 Q3: $423M, +1.0% QoQ 2024 Q3: $423M, +1.0% QoQ
Q3
2024 Q4: $393M, −7.1% QoQ 2024 Q4: $393M, −7.1% QoQ
Q4
2025 Q1: $353M, −10.2% QoQ 2025 Q1: $353M, −10.2% QoQ
Q1 2025
2025 Q2: $362M, +2.5% QoQ 2025 Q2: $362M, +2.5% QoQ
Q2
2025 Q3: $405M, +11.9% QoQ 2025 Q3: $405M, +11.9% QoQ
Q3
2025 Q4: $431M, +6.4% QoQ 2025 Q4: $431M, +6.4% QoQ
Q4
2026 Q1: $440M, +2.1% QoQ 2026 Q1: $440M, +2.1% QoQ
Q1 2026
2026 Q2: $524M, +19.1% QoQ 2026 Q2: $524M, +19.1% QoQ
Q2

Book

2022 Q4 2022 Q3, filed 14 Feb, long equity only

Download CSV Download Excel All activity
XBI, SPDR S&P Biotech ETF 13.23% Hold 566,000 $83.00 $47M — —
STXS, Stereotaxis 7.98% Hold 13,680,554 $2.07 $28M — —
ASND, Ascendis Pharma A/s 4.48% Reduce −4.1% 130,212 $122.13 $16M −5,500 +$1.9M
Karuna Therapeutics 3.99%, was 1.75% Add +149.3% 72,027 $196.50 $14M +43,141 +$7.7M
NDAQ, iShares Nasdaq Biotech Indx 3.79% Hold 102,500 $131.29 $13M — —
Iveric Bio 3.65%, was 1.94% Add +50.9% 605,975 $21.41 $13M +204,499 +$5.8M
XENE, Xenon Pharmaceuticals 3.51%, was 3.64% Reduce −15.8% 316,092 $39.43 $12M −59,131 −$1.1M
Blueprint Medicines 3.22% Hold 261,235 $43.81 $11M — —
RVMD, Revolution Medicines 3.21% Reduce −0.4% 477,785 $23.82 $11M −2,000 +$1.9M
SNDX, Syndax Pharmaceuticals 3.20%, was 2.30% Add +25.8% 447,073 $25.45 $11M +91,586 +$2.8M
NBIX, Neurocrine Biosciences 2.46% Reduce −8.8% 73,121 $119.44 $8.7M −7,034 +$221K
IDYA, Ideaya Biosciences 2.40% Reduce −13.0% 468,358 $18.17 $8.5M −70,203 +$475K
CYTK, Cytokinetics 2.37% Hold 183,995 $45.82 $8.4M — —
DXCM, DexCom 2.15% Reduce −6.9% 67,552 $113.24 $7.6M −5,000 +$1.8M
Sage Therapeutics 1.94% Hold 180,306 $38.14 $6.9M — —
EWTX, Edgewise Therapeutics 1.93%, was 2.07% Reduce −1.8% 766,843 $8.94 $6.9M −14,269 −$830K
NRIX, Nurix Therapeutics 1.75% Hold 566,695 $10.98 $6.2M — —
Adicet Bio 1.59%, was 3.58% Reduce −32.5% 631,554 $8.94 $5.6M −304,212 −$7.7M
FATE, Fate Therapeutics 1.57% Add +2.0% 550,940 $10.09 $5.6M +11,000 −$6.5M
BHVN, Biohaven 1.54%, was 0.26% Add +156.0% 393,113 $13.88 $5.5M +239,549 +$4.5M
Morphic 1.47% Hold 195,467 $26.75 $5.2M — —
ALEC, Alector 1.38% Hold 532,438 $9.23 $4.9M — —
VKTX, Viking Therapeutics 1.38% Reduce −5.6% 521,553 $9.40 $4.9M −30,847 +$3.4M
APLS, Apellis Pharmaceuticals 1.22%, was 1.21% Add +26.5% 83,446 $51.71 $4.3M +17,500 −$189K
Merus 1.18%, was 1.49% Reduce −2.5% 269,893 $15.47 $4.2M −7,000 −$1.4M
Kalvista Pharmaceuticals 1.17%, was 1.00% Add +141.3% 616,032 $6.76 $4.2M +360,719 +$459K
89bio 1.16% Reduce −50.5% 324,173 $12.73 $4.1M −330,689 +$335K
Cardiovascular Systems 1.10% Hold 286,988 $13.62 $3.9M — —
Dice Therapeutics 1.09%, was 0.43% Add +57.3% 123,500 $31.20 $3.9M +45,000 +$2.3M
F-Star Therapeutics 1.03% Hold 576,881 $6.32 $3.6M — —
BCYC, Bicycle Therapeutics 1.02% Hold 122,200 $29.60 $3.6M — —
Mirati Therapeutics 0.94% Add +2.8% 73,600 $45.31 $3.3M +2,000 −$1.7M
AXGN, Axogen 0.93% Hold 332,103 $9.98 $3.3M — —
ATRC, Atricure 0.90% Hold 72,029 $44.38 $3.2M — —
CMPX, Compass Therapeutics 0.85%, was 0.12% Add +220.1% 602,051 $5.03 $3M +413,957 +$2.6M
RCUS, Arcus Biosciences 0.83%, was 1.26% Reduce −20.4% 142,217 $20.68 $2.9M −36,500 −$1.7M
BCRX, Biocryst Pharmaceuticals 0.81% New 251,000 $11.48 $2.9M +251,000 +$2.9M
Mediwound 0.78% New 204,082 $13.49 $2.8M +204,082 +$2.8M
ARAY, Accuray 0.72%, was 0.53% Add +29.8% 1,222,358 $2.09 $2.6M +280,558 +$596K
IPSC, Century Therapeutics 0.69% Hold 475,367 $5.13 $2.4M — —
Mersana Therapeutics 0.68% Add +9.5% 413,463 $5.86 $2.4M +35,700 −$131K
LKFT, Galapagos 0.66%, was 0.49% Add +23.4% 52,675 $44.38 $2.3M +10,000 +$518K
AUTL, Autolus Therapeutics 0.63%, was 0.29% Add +137.1% 1,176,150 $1.90 $2.2M +680,000 +$1.2M
Neuronetics 0.61% Hold 313,717 $6.87 $2.2M — —
Vigil Neuroscience 0.59% Reduce −22.0% 168,846 $12.50 $2.1M −47,549 +$142K
LRMR, Larimar Therapeutics 0.55% Reduce −17.7% 473,136 $4.13 $2M −101,860 +$114K
Iteos Therapeutics 0.54%, was 0.50% Add +1.0% 98,560 $19.53 $1.9M +1,000 +$66K
KURA, Kura Oncology 0.51%, was 0.76% Reduce −29.8% 144,784 $12.41 $1.8M −61,545 −$1M
Keros Therapeutics 0.45% Reduce −15.4% 33,000 $48.02 $1.6M −6,000 +$118K
ORIC, Oric Pharmaceuticals 0.44% Reduce −36.1% 264,237 $5.89 $1.6M −149,289 +$233K

Showing top 50 of 79 by value

Exits / last held

Gone since 2022 Q3, shown at their last reported size.

Stock % of portfolio Recent activity Shares Reported price* Value Share change $ change
BHVN, Biohaven 4.48% Exit 0 $151.17 $17M −110,100 −$17M
Aerie Pharmaceuticals 1.25% Exit 0 $15.13 $4.6M −307,232 −$4.6M
Mediwound 0.53% Exit 0 $1.39 $2M −1,428,571 −$2M
NGM Biopharmaceuticals 0.26% Exit 0 $13.07 $980K −74,953 −$980K
Gamida Cell 0.26% Exit 0 $1.59 $978K −614,896 −$978K
Holding 0.18% Exit 0 $0.3865 $683K −1,767,146 −$683K
GH Research 0.16% Exit 0 $11.63 $612K −52,631 −$612K
CMPS, Compass Pathways 0.14% Exit 0 $10.72 $508K −47,390 −$508K
PRQR, Proqr Therapeutics 0.13% Exit 0 $0.7438 $483K −649,383 −$483K
Sutro Biopharma 0.12% Exit 0 $5.55 $451K −81,200 −$451K
Otonomy 0.12% Exit 0 $0.2952 $434K −1,470,199 −$434K
Venus Concept 0.11% Exit 0 $0.4400 $426K −968,187 −$426K

Weight bar: held both quarters added sold at this quarter’s reported price

* Reported price is value ÷ shares from the 13F as of period end, not a live market quote. Weight % is each long-equity position ÷ full 13F AUM, so rows may not sum to 100% when the filing includes options or other non-equity (excluded from this table). Share change and $ change are vs 2022 Q3. Click a column header to sort, or New, Hold, Add or Reduce to bring those moves to the top. Exit opens the last-held block below.

Filings history

20 periods, with AUM normalized

Newest 13Fs
Period Holds AUM QoQ Form Filed Filing ID
2026 Q2 88 $524M +19.1% 13F-HR 8/14/2026 000138993326000006
2026 Q1 83 $440M +2.1% 13F-HR 5/15/2026 000138993326000004
2025 Q4 77 $431M +6.4% 13F-HR 2/17/2026 000138993326000002
2025 Q3 75 $405M +11.9% 13F-HR 11/14/2025 000138993325000008
2025 Q2 76 $362M +2.5% 13F-HR 8/14/2025 000138993225000011
2025 Q1 83 $353M −10.2% 13F-HR 5/15/2025 000138993325000002
2024 Q4 82 $393M −7.1% 13F-HR 2/14/2025 000138993225000004
2024 Q3 84 $423M +1.0% 13F-HR 11/14/2024 000138993224000020
2024 Q2 83 $419M −4.6% 13F-HR 8/14/2024 000138993224000016
2024 Q1 72 $439M +5.3% 13F-HR 5/15/2024 000138993224000012
2023 Q4 76 $417M +29.9% 13F-HR 2/14/2024 000138993224000004
2023 Q3 75 $321M −12.3% 13F-HR 11/14/2023 000138993223000010
2023 Q2 73 $366M +9.6% 13F-HR 8/14/2023 000138993323000008
2023 Q1 72 $334M −5.9% 13F-HR 5/15/2023 000138993323000006
2022 Q4 79 $355M −4.6% 13F-HR 2/14/2023 000138993323000002
2022 Q3 87 $372M +1.4% 13F-HR 11/14/2022 000138993322000010
2022 Q2 90 $367M −4.4% 13F-HR 8/15/2022 000138993322000008
2022 Q1 94 $384M −3.5% 13F-HR 5/16/2022 000138993322000006
2021 Q4 87 $398M +5.6% 13F-HR 2/14/2022 000138993322000002
2021 Q3 80 $377M — 13F-HR 11/15/2021 000138993321000011

About

DAFNA Capital Management LLC

20 processed 13Fs on this site, 2021 Q3 to 2026 Q2

Entity
DAFNA Capital Management LLC
Notable person
Nathan Fischel
Location
Los Angeles, CA
All SEC filings
View on sec.gov