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DAFNA Capital Management LLC Nathan Fischel

Los Angeles, CA 20 processed 13Fs on this site, 2021 Q3 to 2026 Q2

  • $524M
  • 88 holdings
  • 2026 Q2
  • +19.1% QoQ
  • Top 5 40.2%

Portfolio

2026 Q2, filed 8/14/2026, top 12 of 88 holdings

Top 5 40.2%, top 10 56.2%

  1. RVMD, Revolution Medicines 20.1%
  2. XBI, SPDR S&P Biotech ETF 5.9%
  3. CMPS, Compass Pathways 5.4%
  4. STXS, Stereotaxis 4.5%
  5. NKTR, Nektar Therapeutics 4.3%
  6. DNLI, Denali Therapeutics 3.6%
  7. IDYA, Ideaya Biosciences 3.5%
  8. ATRC, Atricure 3.2%
  9. XENE, Xenon Pharmaceuticals 2.9%
  10. CYTK, Cytokinetics 2.8%
  11. RCUS, Arcus Biosciences 2.6%
  12. ASND, Ascendis Pharma A/s 2.5%
  13. Other 38.7%

AUM over time

2026 Q2 $524M +19.1% QoQ
2021 Q3: $377M 2021 Q3: $377M
Q3 2021
2021 Q4: $398M, +5.6% QoQ 2021 Q4: $398M, +5.6% QoQ
Q4
2022 Q1: $384M, −3.5% QoQ 2022 Q1: $384M, −3.5% QoQ
Q1 2022
2022 Q2: $367M, −4.4% QoQ 2022 Q2: $367M, −4.4% QoQ
Q2
2022 Q3: $372M, +1.4% QoQ 2022 Q3: $372M, +1.4% QoQ
Q3
2022 Q4: $355M, −4.6% QoQ 2022 Q4: $355M, −4.6% QoQ
Q4
2023 Q1: $334M, −5.9% QoQ 2023 Q1: $334M, −5.9% QoQ
Q1 2023
2023 Q2: $366M, +9.6% QoQ 2023 Q2: $366M, +9.6% QoQ
Q2
2023 Q3: $321M, −12.3% QoQ 2023 Q3: $321M, −12.3% QoQ
Q3
2023 Q4: $417M, +29.9% QoQ 2023 Q4: $417M, +29.9% QoQ
Q4
2024 Q1: $439M, +5.3% QoQ 2024 Q1: $439M, +5.3% QoQ
Q1 2024
2024 Q2: $419M, −4.6% QoQ 2024 Q2: $419M, −4.6% QoQ
Q2
2024 Q3: $423M, +1.0% QoQ 2024 Q3: $423M, +1.0% QoQ
Q3
2024 Q4: $393M, −7.1% QoQ 2024 Q4: $393M, −7.1% QoQ
Q4
2025 Q1: $353M, −10.2% QoQ 2025 Q1: $353M, −10.2% QoQ
Q1 2025
2025 Q2: $362M, +2.5% QoQ 2025 Q2: $362M, +2.5% QoQ
Q2
2025 Q3: $405M, +11.9% QoQ 2025 Q3: $405M, +11.9% QoQ
Q3
2025 Q4: $431M, +6.4% QoQ 2025 Q4: $431M, +6.4% QoQ
Q4
2026 Q1: $440M, +2.1% QoQ 2026 Q1: $440M, +2.1% QoQ
Q1 2026
2026 Q2: $524M, +19.1% QoQ 2026 Q2: $524M, +19.1% QoQ
Q2

Book

2022 Q2 2022 Q1, filed 15 Aug, long equity only

Download CSV Download Excel All activity
XBI, SPDR SP Biotech ETF 12.41%, was 6.31% Add +127.5% 613,000 $74.27 $46M +343,500 +$21M
STXS, Stereotaxis 6.86% Hold 13,680,554 $1.84 $25M — —
BHVN, Biohaven 4.37%, was 2.40% Add +41.9% 110,100 $145.71 $16M +32,500 +$6.8M
Adicet Bio 3.72% Add +30.7% 935,766 $14.60 $14M +219,894 −$634K
FATE, Fate Therapeutics 3.72% Add +10.0% 550,940 $24.78 $14M +50,010 −$5.8M
XENE, Xenon Pharmaceuticals 3.64%, was 3.03% Add +15.4% 438,623 $30.42 $13M +58,460 +$1.7M
Blueprint Medicines 3.60% Add +6.1% 261,280 $50.51 $13M +15,000 −$2.5M
ASND, Ascendis Pharma A/s 3.53%, was 0.94% Add +354.8% 139,212 $92.96 $13M +108,600 +$9.3M
NDAQ, Nasdaq Omx 3.29% Hold 102,500 $117.63 $12M — —
CYTK, Cytokinetics 2.26% Hold 211,495 $39.29 $8.3M — —
NBIX, Neurocrine Biosciences 2.20% Reduce −1.2% 82,655 $97.48 $8.1M −1,000 +$214K
Karuna Therapeutics 2.14%, was 2.71% Reduce −24.4% 62,053 $126.50 $7.9M −20,000 −$2.6M
IDYA, Ideaya Biosciences 2.06%, was 1.43% Add +11.9% 548,561 $13.80 $7.6M +58,500 +$2.1M
NRIX, Nurix Therapeutics 1.96% Add +4.3% 566,695 $12.67 $7.2M +23,351 −$432K
SNDX, Syndax Pharmaceuticals 1.95% Reduce −0.3% 370,987 $19.24 $7.1M −1,000 +$673K
Merus 1.62% Add +11.9% 262,891 $22.64 $6M +27,902 −$261K
RVMD, Revolution Medicines 1.59%, was 1.54% Add +29.2% 299,785 $19.49 $5.8M +67,684 −$78K
Sage Therapeutics 1.59% Hold 180,306 $32.30 $5.8M — —
ALEC, Alector 1.53%, was 1.09% Add +88.7% 552,438 $10.16 $5.6M +259,691 +$1.4M
EWTX, Edgewise Therapeutics 1.51%, was 0.90% Add +95.1% 695,959 $7.96 $5.5M +339,209 +$2.1M
DXCM, DexCom 1.47% Add +300.0% 72,552 $74.53 $5.4M +54,414 −$3.9M
Mirati Therapeutics 1.46%, was 0.91% Add +86.4% 79,600 $67.14 $5.3M +36,900 +$1.8M
Cymabay Therapeutics 1.44%, was 1.37% Add +5.6% 1,787,569 $2.95 $5.3M +95,000 +$9K
RCUS, Arcus Biosciences 1.30%, was 1.19% Add +29.3% 187,717 $25.34 $4.8M +42,500 +$174K
Natus Medical 1.28%, was 1.31% Reduce −24.7% 143,600 $32.77 $4.7M −47,035 −$304K
APLS, Apellis Pharmaceuticals 1.19% Add +3.2% 96,935 $45.22 $4.4M +3,000 −$390K
Morphic 1.16% Add +7.7% 195,467 $21.70 $4.2M +14,000 −$3M
Cardiovascular Systems 1.12% Hold 286,988 $14.36 $4.1M — —
IPSC, Century Therapeutics 1.09%, was 0.84% Add +85.0% 475,367 $8.40 $4M +218,475 +$759K
Iveric Bio 1.06% Add +34.8% 402,476 $9.62 $3.9M +104,000 −$1.2M
Holding 0.99% Reduce −18.5% 48,452 $75.25 $3.6M −11,000 +$2.1M
F-Star Therapeutics 0.98% Reduce −16.9% 576,881 $6.26 $3.6M −116,904 +$1.1M
Otonomy 0.83%, was 0.94% Reduce −1.8% 1,470,199 $2.08 $3.1M −27,315 −$536K
ATRC, Atricure 0.80% Hold 72,029 $40.86 $2.9M — —
Kinnate Biopharma 0.77%, was 0.43% Add +51.5% 224,451 $12.61 $2.8M +76,300 +$1.2M
AXGN, Axogen 0.74% Hold 332,103 $8.19 $2.7M — —
Kalvista Pharmaceuticals 0.71% Add +39.3% 265,663 $9.84 $2.6M +75,000 −$196K
89bio 0.67%, was 0.32% Add +136.6% 766,774 $3.22 $2.5M +442,721 +$1.2M
Dice Therapeutics 0.66%, was 0.47% Add +66.9% 156,904 $15.52 $2.4M +62,904 +$637K
LKFT, Galapagos 0.65% Hold 42,675 $55.79 $2.4M — —
BCYC, Bicycle Therapeutics 0.60% Add +146.6% 131,200 $16.78 $2.2M +78,000 −$132K
Iteos Therapeutics 0.59% Add +17.9% 105,298 $20.60 $2.2M +16,000 −$705K
Aerie Pharmaceuticals 0.59% Hold 289,040 $7.50 $2.2M — —
KURA, Kura Oncology 0.59%, was 0.47% Add +4.0% 117,829 $18.33 $2.2M +4,500 +$338K
Affimed 0.52% Add +20.1% 686,282 $2.77 $1.9M +115,000 −$596K
Mersana Therapeutics 0.51%, was 0.37% Add +15.3% 406,763 $4.62 $1.9M +54,000 +$471K
ORIC, Oric Pharmaceuticals 0.51% New 415,926 $4.48 $1.9M +415,926 +$1.9M
ARAY, Accuray 0.50% Hold 941,800 $1.96 $1.8M — —
Surface Oncology 0.49% Add +61.8% 1,100,000 $1.64 $1.8M +420,000 −$195K
BMEA, Biomea Fusion 0.45% Reduce −64.3% 136,935 $11.98 $1.6M −246,988 −$72K

Showing top 50 of 88 by value

Exits / last held

Gone since 2022 Q1, shown at their last reported size.

Stock % of portfolio Recent activity Shares Reported price* Value Share change $ change
Holding 0.57% Exit 0 $13.50 $2.2M −160,983 −$2.2M
COGT, Cogent Biosciences 0.44% Exit 0 $7.49 $1.7M −223,554 −$1.7M
Regulus Therapeutics 0.43% Exit 0 $0.2981 $1.7M −5,555,555 −$1.7M
Immunocore 0.42% Exit 0 $29.90 $1.6M −53,878 −$1.6M
PHVS, Pharvaris 0.16% Exit 0 $18.14 $628K −34,615 −$628K
Harpoon Therapeutics 0.14% Exit 0 $4.97 $523K −105,163 −$523K
Surgalign 0.05% Exit 0 $0.3036 $176K −579,710 −$176K
Infinity Pharmaceuticals 0.04% Exit 0 $1.14 $137K −120,097 −$137K

Weight bar: held both quarters added sold at this quarter’s reported price

* Reported price is value ÷ shares from the 13F as of period end, not a live market quote. Weight % is each long-equity position ÷ full 13F AUM, so rows may not sum to 100% when the filing includes options or other non-equity (excluded from this table). Share change and $ change are vs 2022 Q1. Click a column header to sort, or New, Hold, Add or Reduce to bring those moves to the top. Exit opens the last-held block below.

Filings history

20 periods, with AUM normalized

Newest 13Fs
Period Holds AUM QoQ Form Filed Filing ID
2026 Q2 88 $524M +19.1% 13F-HR 8/14/2026 000138993326000006
2026 Q1 83 $440M +2.1% 13F-HR 5/15/2026 000138993326000004
2025 Q4 77 $431M +6.4% 13F-HR 2/17/2026 000138993326000002
2025 Q3 75 $405M +11.9% 13F-HR 11/14/2025 000138993325000008
2025 Q2 76 $362M +2.5% 13F-HR 8/14/2025 000138993225000011
2025 Q1 83 $353M −10.2% 13F-HR 5/15/2025 000138993325000002
2024 Q4 82 $393M −7.1% 13F-HR 2/14/2025 000138993225000004
2024 Q3 84 $423M +1.0% 13F-HR 11/14/2024 000138993224000020
2024 Q2 83 $419M −4.6% 13F-HR 8/14/2024 000138993224000016
2024 Q1 72 $439M +5.3% 13F-HR 5/15/2024 000138993224000012
2023 Q4 76 $417M +29.9% 13F-HR 2/14/2024 000138993224000004
2023 Q3 75 $321M −12.3% 13F-HR 11/14/2023 000138993223000010
2023 Q2 73 $366M +9.6% 13F-HR 8/14/2023 000138993323000008
2023 Q1 72 $334M −5.9% 13F-HR 5/15/2023 000138993323000006
2022 Q4 79 $355M −4.6% 13F-HR 2/14/2023 000138993323000002
2022 Q3 87 $372M +1.4% 13F-HR 11/14/2022 000138993322000010
2022 Q2 90 $367M −4.4% 13F-HR 8/15/2022 000138993322000008
2022 Q1 94 $384M −3.5% 13F-HR 5/16/2022 000138993322000006
2021 Q4 87 $398M +5.6% 13F-HR 2/14/2022 000138993322000002
2021 Q3 80 $377M — 13F-HR 11/15/2021 000138993321000011

About

DAFNA Capital Management LLC

20 processed 13Fs on this site, 2021 Q3 to 2026 Q2

Entity
DAFNA Capital Management LLC
Notable person
Nathan Fischel
Location
Los Angeles, CA
All SEC filings
View on sec.gov