Follow-The-Filings

Featured 13F manager

Palo Alto Investors LP Palo Alto Investors

Palo Alto, CA 23 processed 13Fs on this site · 2021 Q3–2026 Q2

  • $724M
  • 52 Positions
  • 2026 Q2
  • +10.7% QoQ
  • Top 5 37.7%

Palo Alto Investors files Palo Alto Investors LP as a Form 13F. The latest book is 2026 Q2 at $724M, up 10.7% QoQ, led by Ptc Therapeutics, Acadia Pharmaceuticals, and Insmed.

Portfolio

2026 Q2 · filed 8/19/2026 · 52 long · top 12 shown

top 5 37.7% · top 10 61.3%

AUM over time

2026 Q2 $724M +10.7% QoQ
2021 Q3 · $1.7B 2021 Q3 · $1.7B
Q3 2021
2021 Q4 · $1.6B · −5.6% QoQ 2021 Q4 · $1.6B · −5.6% QoQ
Q4
2022 Q1 · $1.3B · −17.4% QoQ 2022 Q1 · $1.3B · −17.4% QoQ
Q1 2022
2022 Q2 · $1.1B · −11.3% QoQ 2022 Q2 · $1.1B · −11.3% QoQ
Q2
2022 Q3 · $1.3B · +10.3% QoQ 2022 Q3 · $1.3B · +10.3% QoQ
Q3
2022 Q4 · $1.2B · −7.3% QoQ 2022 Q4 · $1.2B · −7.3% QoQ
Q4
2023 Q1 · $1.2B · +2.9% QoQ 2023 Q1 · $1.2B · +2.9% QoQ
Q1 2023
2023 Q2 · $1.2B · +2.6% QoQ 2023 Q2 · $1.2B · +2.6% QoQ
Q2
2023 Q3 · $1.1B · −14.6% QoQ 2023 Q3 · $1.1B · −14.6% QoQ
Q3
2023 Q4 · $1.1B · +4.7% QoQ 2023 Q4 · $1.1B · +4.7% QoQ
Q4
2024 Q1 · $887M · −19.9% QoQ 2024 Q1 · $887M · −19.9% QoQ
Q1 2024
2024 Q2 · $863M · −2.7% QoQ 2024 Q2 · $863M · −2.7% QoQ
Q2
2024 Q3 · $770M · −10.8% QoQ 2024 Q3 · $770M · −10.8% QoQ
Q3
2024 Q4 · $645M · −16.2% QoQ 2024 Q4 · $645M · −16.2% QoQ
Q4
2025 Q1 · $525M · −18.6% QoQ 2025 Q1 · $525M · −18.6% QoQ
Q1 2025
2025 Q2 · $470M · −10.5% QoQ 2025 Q2 · $470M · −10.5% QoQ
Q2
2025 Q3 · $540M · +14.9% QoQ 2025 Q3 · $540M · +14.9% QoQ
Q3
2025 Q4 · $718M · +33.0% QoQ 2025 Q4 · $718M · +33.0% QoQ
Q4
2026 Q1 · $654M · −8.9% QoQ 2026 Q1 · $654M · −8.9% QoQ
Q1 2026
2026 Q2 · $724M · +10.7% QoQ 2026 Q2 · $724M · +10.7% QoQ
Q2

Book

2022 Q4 2022 Q3 · filed 14 Feb · long equity

BMRN - Biomarin Pharmaceutical 16.64% Reduce −4.6% 1,885,811 $103.49 $195M −90,454 +$28M
UTHR - United Therapeutics 14.83% Reduce −1.3% 625,414 $278.09 $174M −8,120 +$41M
FOLD - Amicus 10.92% Add +6.6% 10,493,722 $12.21 $128M +645,948 +$25M
INSM - Insmed 10.00% Add +0.5% 5,871,291 $19.98 $117M +30,893 −$8M
BIIB - Biogen 8.97% Add +5.3% 380,082 $276.92 $105M +19,101 +$9M
PRTA - Prothena 8.52% Add +0.5% 1,658,577 $60.25 $100M +8,800 −$97K
Revance Therapeutics 8.32% Add +19.9% 5,283,609 $18.46 $98M +878,570 −$21M
Staar Surgical 5.13% Add +13.1% 1,240,077 $48.54 $60M +143,195 −$17M
ACAD - Acadia Pharmaceuticals 3.23% Add +41.6% 2,376,369 $15.92 $38M +698,173 +$10M
Sage Therapeutics 2.79% Add +0.6% 856,517 $38.14 $33M +5,108 −$673K
Karyopharm Therapeutics 1.64% Add +0.6% 5,655,676 $3.40 $19M +34,143 −$11M
ALKS - Alkermes 1.34% Hold 603,400 $26.13 $16M
ALGN - Align Technology 1.34% Add +68.4% 74,605 $210.90 $16M +30,300 +$7M
SNDX - Syndax Pharmaceuticals 1.33% Hold 612,600 $25.45 $16M
ANAB - Anaptysbio 1.14% Hold 431,024 $30.99 $13M
EHTH - Ehealth 1.03% Add +25.6% 2,484,479 $4.84 $12M +506,486 +$4M
VNDA - Vanda Pharmaceuticals 0.69% Reduce −49.8% 1,087,607 $7.39 $8M −1,078,549 −$13M
CYTK - Cytokinetics 0.44% Hold 111,717 $45.82 $5M
Kezar Life Sciences 0.39% Hold 656,200 $7.04 $5M
Provention Bio 0.35% Hold 390,800 $10.57 $4M
TVTX - Travere Therapeutics 0.30% Hold 166,069 $21.03 $3M
Gritstone Oncology 0.20% Reduce −71.4% 666,127 $3.45 $2M −1,664,377 −$4M
Peak Bio 0.17% New 497,528 $4.06 $2M +497,528 +$2M
MIRM - Mirum Pharmaceuticals 0.11% Hold 64,700 $19.50 $1M
ALDX - Aldeyra Therapeutics 0.10% Hold 160,800 $6.96 $1M
Alimera Sciences 0.05% Hold 200,919 $2.71 $544K
Holding 0.03% Hold 27,100 $11.48 $311K
URGN - Urogen Pharma 0.02% Hold 24,500 $8.87 $217K
Gossamer Bio 0.01% Reduce −97.8% 37,750 $2.17 $82K −1,712,901 −$21M

Exits / last held

not current holdings · last reported size, unchanged · gone vs 2022 Q3

Stock % of portfolio Recent activity Shares Reported price* Value Share change $ change
Abiomed 9.53% Exit 0 $245.66 $121M −490,754 −$121M
Clovis Oncology 0.42% Exit 0 $1.19 $5M −4,473,967 −$5M
Magenta Therapeutics 0.05% Exit 0 $1.41 $610K −432,300 −$610K
Marinus Pharmaceuticals 0.02% Exit 0 $6.64 $208K −31,330 −$208K

* Reported price is value ÷ shares from the 13F as of period end — not a live market quote. Weight % is each long-equity position ÷ full 13F AUM, so rows may not sum to 100% when the filing includes options or other non-equity (excluded from this table). Share change and $ change are vs 2022 Q3. Click column headers to sort · click New / Hold / Add / Reduce to promote that move type to the top. Exit opens the last-held block below.

Filings history

20 periods · normalized AUM · open a period for holdings

Period Holdings AUM QoQ Form Filed Filing ID
2026 Q2 52 $724M +10.7% RESTATEMENT 8/19/2026 000207367926000102
2026 Q2 52 $724M RESTATEMENT 8/18/2026 000207367926000101
2026 Q2 52 $724M 13F-HR 8/17/2026 000207367926000096
2026 Q1 51 $654M −8.9% 13F-HR 5/15/2026 000130692326000004
2025 Q4 49 $718M +33.0% 13F-HR 2/17/2026 000130692326000002
2025 Q3 44 $540M +14.9% 13F-HR 11/14/2025 000130692325000019
2025 Q2 45 $470M −10.5% 13F-HR 8/14/2025 000130692325000016
2025 Q1 44 $525M −18.6% 13F-HR 5/15/2025 000130692325000014
2024 Q4 43 $645M −16.2% 13F-HR 2/14/2025 000130692325000010
2024 Q3 45 $770M −10.8% 13F-HR 11/14/2024 000130692324000012
2024 Q2 39 $863M −2.7% 13F-HR 8/14/2024 000130692324000010
2024 Q1 38 $887M −19.9% 13F-HR 5/15/2024 000130692324000008
2023 Q4 34 $1.1B RESTATEMENT 2/15/2024 000130692324000007
2023 Q4 34 $1.1B +4.7% 13F-HR 2/14/2024 000130692324000002
2023 Q3 29 $1.1B −14.6% 13F-HR 11/14/2023 000130692323000014
2023 Q2 30 $1.2B +2.6% 13F-HR 8/14/2023 000130692323000012
2023 Q1 30 $1.2B +2.9% 13F-HR 5/15/2023 000130692323000011
2022 Q4 29 $1.2B −7.3% 13F-HR 2/14/2023 000130692323000009
2022 Q3 32 $1.3B +10.3% 13F-HR 11/14/2022 000130692322000016
2022 Q2 33 $1.1B −11.3% 13F-HR 8/15/2022 000130692322000015
2022 Q1 35 $1.3B −17.4% 13F-HR 5/16/2022 000130692322000014
2021 Q4 37 $1.6B −5.6% 13F-HR 2/14/2022 000130692322000004
2021 Q3 42 $1.7B 13F-HR 11/15/2021 000130692321000026

About

Palo Alto Investors LP

23 processed 13Fs on this site · 2021 Q3–2026 Q2

Entity
Palo Alto Investors LP
Notable person
Palo Alto Investors
Location
Palo Alto, CA
All SEC filings
View on sec.gov