VRTX Vertex Pharmaceuticals

• None no insider bought on the open market
• None no sales outside a trading plan
• $158M sold by 13 insiders under 10b5-1 plans

1. Insider
   Trade
   Value
   Traded, filed
2. Ourania Tatsis EVP, Chief Reg. & Quality Off.
   Planned sale
   $787K 1,500 shares at $524.99 3.2% of stake
   Traded Jul 2 Filed Jul 7
   ↗
3. Duncan McKechnie EVP, Chief Commercial Officer
   Planned sale
   $800K 1,541 shares at $519.00 12% of stake
   Traded Jul 2 Filed Jul 7
   ↗
4. Joy Liu EVP and Chief Legal Officer
   Planned sale
   $416K 828 shares at $502.71 4.1% of stake
   Traded Jul 1 Filed Jul 6
   ↗
5. Carmen Bozic EVP and CMO
   Planned sale
   $288K 596 shares at $482.50 3.7% of stake
   Traded Jun 26 Filed Jun 30
   ↗
6. Carmen Bozic EVP and CMO
   Planned sale
   $471K 1,020 shares at $462.17 6% of stake
   Traded Jun 18 Filed Jun 23
   ↗
7. Carmen Bozic EVP and CMO
   Planned sale
   $1.8M 4,062 shares at $450.00 19% of stake
   Traded Jun 15 Filed Jun 17
   ↗
8. Carmen Bozic EVP and CMO
   Planned sale
   $785K 1,745 shares at $450.00 7.7% of stake
   Traded Jun 5 Filed Jun 9
   ↗
9. Joy Liu EVP and Chief Legal Officer
   Planned sale
   $364K 828 shares at $439.91 4% of stake
   Traded Jun 1 Filed Jun 3
   ↗
10. Carmen Bozic EVP and CMO
    Planned sale
    $888K 1,974 shares at $450.00 8% of stake
    Traded May 29 Filed Jun 2
    ↗
11. Mark E. Bunnage EVP, Chief Scientific Officer
    Planned sale
    $15K 33 shares at $453.45 0.5% of stake
    Traded May 15 Filed May 19
    ↗
12. Carmen Bozic EVP and CMO
    Planned sale
    $614K 1,354 shares at $453.45 5.2% of stake
    Traded May 15 Filed May 19
    ↗
13. Carmen Bozic EVP and CMO
    Planned sale
    $3.1M 6,988 shares at $450.00 21% of stake
    Traded May 12 Filed May 14
    ↗
14. Joy Liu EVP and Chief Legal Officer
    Planned sale
    $469K 1,104 shares at $425.02 5.1% of stake
    Traded May 1 Filed May 5
    ↗
15. Sangeeta N. Bhatia Director
    Planned sale
    $135K 318 shares at $423.73 6.1% of stake
    Traded May 4 Filed May 5
    ↗
16. Joy Liu EVP and Chief Legal Officer
    Planned sale
    $439K 978 shares at $449.17 4.3% of stake
    Traded Apr 1 Filed Apr 3
    ↗

Also filed in the last 12 months, not counted as buying or selling: 42 stock grants, 42 share withholdings for taxes, 8 option exercises, 4 sales back to the company, and 2 gifts.