SYRE Spyre Therapeutics

• None no insider bought on the open market
• $401M sold by 2 insiders outside a trading plan
• $40.4M sold by 6 insiders under 10b5-1 plans

1. Insider
   Trade
   Value
   Traded, filed
2. Heidy King-Jones See Remarks
   Planned sale
   $2.6M 28,933 shares at $91.03 91% of stake
   Traded Oct 1 Filed Oct 2
   ↗
3. Cameron Turtle CEO
   Planned sale
   $1.4M 15,000 shares at $92.01 2.7% of stake
   Traded Oct 1 Filed Oct 2
   ↗
4. Scott L Burrows CFO
   Planned sale
   $2.3M 25,000 shares at $90.47 24% of stake
   Traded Sep 30–Oct 1 Filed Oct 2
   ↗
5. Heidy King-Jones See Remarks
   Planned sale
   $2.5M 28,399 shares at $87.35 91% of stake
   Traded Sep 1–2 Filed Sep 3
   ↗
6. Scott L Burrows CFO
   Planned sale
   $655K 7,500 shares at $87.31 7.1% of stake
   Traded Sep 1 Filed Sep 3
   ↗
7. Cameron Turtle CEO
   Planned sale
   $1.3M 15,000 shares at $87.29 2.6% of stake
   Traded Sep 1 Filed Sep 3
   ↗
8. Jeffrey W. Albers Director
   Planned sale
   $2.4M 23,000 shares at $104.53
   Traded Aug 7 Filed Aug 10
   ↗
9. Scott L Burrows CFO
   Planned sale
   $717K 7,500 shares at $95.57 7.1% of stake
   Traded Aug 3 Filed Aug 5
   ↗
10. Cameron Turtle CEO
    Planned sale
    $1.4M 15,000 shares at $95.51 2.6% of stake
    Traded Aug 3 Filed Aug 5
    ↗
11. Scott L Burrows CFO
    Planned sale
    $658K 7,500 shares at $87.74 7.1% of stake
    Traded Jul 1 Filed Jul 2
    ↗
12. Sheldon Sloan Chief Medical Officer
    Planned sale
    $731K 8,334 shares at $87.70 100% of stake
    Traded Jul 1 Filed Jul 2
    ↗
13. Cameron Turtle CEO
    Planned sale
    $1.3M 15,000 shares at $87.69 2.5% of stake
    Traded Jul 1 Filed Jul 2
    ↗
14. Scott L Burrows CFO
    Sale
    $1.3M 15,000 shares at $87.13 13% of stake
    Traded Jun 25 Filed Jun 26
    ↗
15. Michael Thomas Henderson Director
    Planned sale
    $2M 20,000 shares at $100.00 23% of stake
    Traded Jun 22 Filed Jun 23
    ↗
16. Fairmount Funds Management LLC Director, +3 joint filers
    Sale
    $400M 4,684,781 shares at $85.31 100% of stake
    Traded Jun 23 Filed Jun 23
    ↗

Also filed in the last 12 months, not counted as buying or selling: 18 option exercises, 1 conversion, 1 other transaction, and 1 sale to cover taxes.