manager	shares	port %	label
Palo Alto Investors	5,102,193	0.51%		history
Nathan Fischel - Dafna Capital Management	192,678	0.04%		history
James Silverman - Opaleye Management	1,425,000	0.28%	New	history
David Witzke - Avidity Partners Management	2,018,500	0.07%	Reduce	history